In situ gelation properties of a collagen

In situ gelation properties of a collagen-genipin sol with a potential for the treatment of gastrointestinal ulcers Takefumi Narita Shunji Yunoki Yoshimi Ohyabu Naohisa Yahagi Toshio Uraoka Cancer Center (Advanced Minimally Invasive Therapy Unit) Research output:

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Enhanced antitumor activity of rapamycin and genipin a

Jan 31 2017Therefore we evaluated whether adding genipin a UCP-2 inhibitor to rapamycin has better antitumor effect in lung cancer Methods: We combined the treatment of genipin and rapamycin in human lung cancer A549 H460 and CL1-0 cells Then we treated the cancer

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Enhancement of active compound genipin from Gardeniae

After absorption into the human body geniposide and genipin exhibit various pharmaceutical activities including anti-inflammatory (Koo et al 2004b) antioxidant (Wang et al 2015) choleretic (Shoda et al 2004) and anti-cancer

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Sporicidal efficacy of genipin: a potential theoretical

Genipin is reported to be a benign crosslinking agent that strengthens mechanical properties of tissues however the antimicrobial capacity of genipin is largely unknown The present study's aims were: (1) to assess the sporicidal potential of genipin (2) to improve antimicrobial capacity by changing chemical and physical treatment conditions

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Genipin Ameliorates Carbon Tetrachloride

Genipin as the most effective ingredient of various traditional medications encompasses antioxidative anti-inflammatory and antibacterial capacities More recently it is suggested that genipin protects against septic liver damage by restoring autophagy The purpose of the current study was to explore the protective effect of genipin

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Antitumor Effects of Genipin: New and Emerging Insights

cancer cells Genipin also increase tissue inhibitors of metalloproteases (MMP) resulting to decrease activities of MMP-2 which plays a key role in metastasis of cancers Genipin has shown a biphasic effects on cell death and survival in cancer cells as many other plant-derived phytochemicals do

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Geniposide and geniposidic acid modified forms of genipin

Genipin has been demonstrated to induce apoptosis in various cell lines but in this paper the apoptosis effect was found attenuated significantly in KGN cell line after when its functional groups was modified which is a reliable tumor cell line of granulosa cell Furthermore geniposide and geniposidic acid chemicals modified from genipin were discovered to retain the anti-inflammatory

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Genipin induces mitochondrial dysfunction and

Jul 27 2019Genipin is a compound derived from gardenia fruit extract Although Genipin has anti-tumor effects in various cancers its effect and mechanism in gastric cancer remain unclear Here we investigated the relationship between the anticancer effect of Genipin and signal transducer and activator of transcription (Stat3)/myeloid cell leukemia-1 (Mcl-1) in human gastric cancers

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Effect of Genipin on Cisplatin

Genipin on Cisplatin-Induced Nephrotoxicity hereby solemnly declare that this thesis is original research work that has been done and prepared by me under the supervision of Dr Rajesh Mohanraj in the College of Medicine and Health Sciences at UAEU This work has not previously been presented or

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Genipin by Triveni Chemicals Supplier from India Product

Genipin is an excellent natural cross-linker for protein collagen gelatin and chitosan cross-linking Based on the non-toxic side effects and the good anti-cancer activeness crocetin is playing an important role in regulation on the circulatory system anti-tumor liver and gallbladder kidney etc

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Genipin

Genipin also exerts anticancer activity as it increases the Bax/Bcl-2 ratio and induces PARP cleavage and caspase-3- and caspase-9-mediated apoptosis in non-small cell lung cancer (NSCLC) cells In animal models this compound upregulates nNOS and decreases acute inflammation through inhibition of LPS-induced NF-κB activity

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Natural Products for Chemoprevention of Breast Cancer

Genipin has anti-proliferative activity in MDA--231 breast cancer cells 6 Genipin induces apoptosis in MDA--231 cells by downregulating Bcl-2 and upregulating Bax and caspase-3 as well as the pro-apoptosis products JNK and p38 MAPK inducing apoptosis and inhibiting invasion/metastasis 6 Genipin was shown to be a chemopreventive agent

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cancer

genipin cancer $35 50 - $48 50 / Kilogram 1 Kilogram (Min Order) Professional reasonable supplier polydatin for anti cancer with certificate $50 00 - $230 00 / Kilogram 1 Kilogram (Min Order) Professional Manufacturer vitamin b17 cancer cure With Technical Support $280 00 - $320 00 /

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Genipin crosslinking of cartilage enhances resistance to

May 18 2015Genipin is considered to be cell-tolerated 12-14 and has been used to crosslink cellular and acellular tissues 16-19 as well as biomaterials such as chitosan and chitosan composites 20 21 gelatin 22-24 and polyethylene glycol hydrogels 25 26 Genipin

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(A) Presumable mechanism of amino group with genipin

Conclusion: Genipin can be used as an alternative crosslinking agent for pericardial tissue considering given its physical mechanical biochemical characteristics and low cytotoxicity comparable to glutaraldehyde However further studies are needed on the immune reaction and the long term changes in genipin-fixed tissues in the human body

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Open Access Full Text Article Genipin Induces Autophagy

Keywords: genipin oral squamous cell carcinoma autophagy PI3K/AKT/mTOR pathway Introduction Oral cancer is an increasing threat worldwide with around 640 000 new cases being detected annually globally 1 2 In addition there are 145 000 deaths per year in oral cancer 3 and five-year survival rates of patients with advanced oral cancer are

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Signal transducer and activator of transcription 3 pathway

Suk-young Lee Hong Jun Kim Sang Cheul Oh and Dae-Hee Lee Genipin inhibits the invasion and migration of colon cancer cells by the suppression of HIF-1α accumulation and VEGF expression Food and Chemical Toxicology 10 1016/j fct 2018 04 005 116 (70-76) (2018)

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Potential role of genipin in cancer therapy

Potential role of genipin in cancer therapy 1 Introduction In contemporary medicine synthetic drugs play an important role in the cure of several diseases 2 In vitro anti-cancer effects of genipin Genipin has been reported to inhibit the proliferation of several cancer

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FOS

The cancer susceptibility candidate 9 (CASC9) gene has been reported to exert an oncogenic effect in several types of cancer However its role in lung squamous cell carcinoma (LUSC) is unknown In addition our study also investigated the effect of genipin (GNP) which is an active compound from Gardenia jasminoides Ellis fruit (family

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